Nebulized Bacteriophage in a Patient With Refractory Mycobacterium abscessus Lung Disease.

12 Apr 2022
Dedrick RM, Freeman KG, Nguyen JA, Bahadirli-Talbott A, Cardin ME, Cristinziano M, Smith BE, Jeong S, Ignatius EH, Lin CT, Cohen KA, Hatfull GF

An elderly man with refractory lung disease previously developed anti-phage neutralizing antibodies while receiving intravenous phage therapy. Subsequent phage nebulization resulted in transient weight gain, decreased C-reactive protein, and reduced burden. Weak sputum neutralization may have limited the outcomes, but phage resistance was not a contributing factor.