Evolution and transmission of cefiderocol-resistant Acinetobacter baumannii during an outbreak in the burn intensive care unit.

17 Aug 2022
Smoke SM, Brophy A, Reveron S, Iovleva A, Kline EG, Marano M, Miller LP, Shields RK

We report 11 critically-ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and inter-patient transmission of cefiderocol-resistant A. baumannii between patients. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.