Chen and Ren

Pilot Study of Lineage Plasticity Along Airway Epithelial Differentiation in Response to Pro-inflammatory Stimulation

Our project aims to address the rising incidence of chronic respiratory diseases, affecting over 35 million Americans, predominantly triggered by increased exposure to airborne pollutants. This issue is particularly critical for children, whose developing lungs are more susceptible to such pollutants. Common to these disorders is uncontrolled lung tissue inflammation and reduced mucociliary clearance, leading to further complications. Our research focuses on the delicate balance between mucus-producing goblet cells and multiciliated cells in the airway, exploring the potential for lineage transition between these cells amid pollutant-induced inflammation. Our findings could illuminate new pathways for therapeutic interventions and personalized disease management.